engleski

Topological signals in integral membrane proteins

The frequency of membrane proteins in genomes of different organisms is 20-30%. Integral membrane proteins pass one or more times through phospholipid membrane, so that simple two-dimensional models of their transmembrane structure can be created. The topological model is complete when protein orientation is known as well. It is the information about cytoplasmatic or extracytoplasmatic location of protein N-terminus that defines its transmembrane helices. Their sequence locations can be determined by using hydrophobicity analysis of the protein sequences. Protein transmembrane orientation can also be predicted from its sequence if topological signals are found in the sequence. We show what are the most useful and the most accurate topological signals for predicting membrane protein N-terminus location.

topological signals; membrane proteins

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