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Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells (CROSBI ID 198761)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Topić, Iva ; Ikić, Marina ; Ivčević, Sanja ; Kovačič, Nataša ; Marušić, Ana ; Kušec, Rajko ; Grčević, Danka Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells // Leukemia research, 37 (2013), 6; 705-712. doi: 10.1016/j.leukres.2013.03.002

Podaci o odgovornosti

Topić, Iva ; Ikić, Marina ; Ivčević, Sanja ; Kovačič, Nataša ; Marušić, Ana ; Kušec, Rajko ; Grčević, Danka

engleski

Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.

Acute promyelocytic leukemia; Bone morphogenetic proteins; All-trans retinoic acid; Differentiation; ID genes; Cell lines; Patients

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Podaci o izdanju

37 (6)

2013.

705-712

objavljeno

0145-2126

10.1016/j.leukres.2013.03.002

Povezanost rada

Temeljne medicinske znanosti

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