ANTINEOPLASTIC DNA-BINDING COMPOUNDS: INTERCALATING AND MINOR GROOVE BINDING DRUGS (CROSBI ID 199258)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Mišković, Katarina ; Bujak, Maro ; Baus Lončar, Mirela ; Glavaš-Obrovac, Ljubica
engleski
ANTINEOPLASTIC DNA-BINDING COMPOUNDS: INTERCALATING AND MINOR GROOVE BINDING DRUGS
DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and/or II poisons, while the mechanisms of DNA minor groove binders are a combination of several steps including topoisomerase poisoning. This paper gives an overview of some of the developed DNA intercalating and minor groove binding compounds, as well as an explanation of their chemical structures, origins, and application in chemotherapy.
chemotherapy; DNA intercalator; DNA minor groove binder; organic compounds
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Podaci o izdanju
64
2013.
593-602
objavljeno
0004-1254
10.2478/10004-1254-64-2013-2371
Povezanost rada
Kemija, Temeljne medicinske znanosti, Biologija