Variants of the IL-23R and STAT3 gene are not associated with Hashimoto’s thyroiditis (CROSBI ID 604681)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Glavaš-Obrovac, Ljubica ; Suver Stević, Mirjana ; Štefanić, Mario ; Tokić, Stana ; Mihaljević, Silvio ; Karner, Ivan
engleski
Variants of the IL-23R and STAT3 gene are not associated with Hashimoto’s thyroiditis
Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto’s thyroiditis (HT), is not fully understood. In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL- 23R(rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products. None of the tested SNPs or IL-23R haplotypes were associated with HT susceptibility or disease severity. These results suggest that the studied IL-23R/STAT3 polymorphisms affecting Th17 signaling efficiency are not major determinants of HT risk in the Croatian population. Further work is necessary to determine if these loci contribute modestly or conditionally to the risk of HT.
St. Petersburg ; Russia
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Podaci o prilogu
459-459.
2013.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
The FEBS journal
John Wiley & Sons
1742-464X
1742-4658
Podaci o skupu
38th FEBS Congress: Mechanisms in Biology
poster
06.07.2013-11.07.2013
Sankt Peterburg, Ruska Federacija