Regional differences in dendritic morphology and spine density of striatal medium spiny neurons in Foxp2 mice (CROSBI ID 604951)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Bicanic, Ivana ; Bornschein, Ulrich ; Enard, Wolfgang ; Hevers, Wulf, Paabo, Svante ; Petanjek, Zdravko
engleski
Regional differences in dendritic morphology and spine density of striatal medium spiny neurons in Foxp2 mice
The extent of language capability sets humans apart from their closest living relatives, the chimpanzees. The transcription factor FOXP2 (Forkhead box protein P2), which is required for speech and language development, carries two amino acid substitutions (T303N, N325S) on the hominine lineage which were likely positively selected during human evolution. When the human variant of the FOXP2 protein is expressed in mice (Enard et al, Cell 137:861, 2009), these animals show an increased dendritic complexity of neurons that are a part of the basal ganglia circuitry and highly express FOXP2, e.g. striatal medium spiny neurons (MSN) (Reimers-Kipping et al, Neuroscience 175:75, 2011). Here, we analyze regional differences in dendritic morphology and spine density of Golgi-Cox impregnated MSN in mice homozygous for the Foxp2 human variant and in two additional mouse strains where one carries only the threonine-to-asparagine substitution at position 302 (T302N ; N303 in humans) while the other carries the asparagine-to-serine at position 324 (N324S ; S325 in humans) in their endogenous Foxp2 gene. Differences in dendritic morphology and spine density appear to be most pronounced in mice expressing the FOXP2 variant with the T302N substitution which is - in contrast to the N324S mutation – uniquely found in humans.
speech development; cortico-striatal circuitry; GABA; glutamate; dopamine
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Podaci o prilogu
231-231.
2013.
objavljeno
Podaci o matičnoj publikaciji
FENS Featured Regional Meeting Abstract Book
Prag:
978-80-260-4881-7
Podaci o skupu
FENS Featured Regional Meeting 2013
poster
11.09.2013-14.09.2013
Prag, Češka Republika