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Pregled bibliografske jedinice broj: 667005

Zbornik radova

Autori: Šalković-Petrišić, Melita; Knezović, Ana; Knapić, Marina; Šimić, Goran
Naslov: Amyloid-β pathology in the brain of a streptozotocin rat model of sporadic Alzheimer’s disease
Izvornik: Clinical Neuropathology 31(4) / Ironside, James (ur.). - Edinburgh : British Neuropathological Society , 2012. 290-290.
Dio CC časopisa: DA
Skup: 10th European Congress of Neuropathology
Mjesto i datum: Edinburgh, Škotska, 06-09.06.2012.
Ključne riječi: amyloid-beta; streptozotocin; angiopathy
Sažetak:
Introduction: Streptozotocin-intracerebroventricularly (STZ-icv) treated rats represent experimental non-transgenic model of sporadic Alzheimer´s disease (sAD) which develop cerebral amyloid pathology in the form of β-amyloid aggregation in the blood vessel wall, found three months after icv administration of 3 mg/kg STZ dose. We have investigated the STZ-icv dose-dependency of β-amyloid pathology development 1 week and 3 months after the STZ-icv treatment. Methods: Adult male Wistar rats were administered STZ (0.1, 1 and 3 mg/kg dose) or vehicle (controls) icv injections and sacrificed 1 week and 3 months afterwards. Paraffin-embedded brain sections of pre-mortally fixative perfused animals were analysed by Congo Red and Bielschowsky Silver staining and Aβ1-42 immunohistochemistry. Results: Congo Red staining revealed β-amyloid aggregation in the meningeal capillaries only with the highest STZ-icv dose 3 months following the treatment with no specific signal being found with lower doses and at 1 week time-point. This finding has been supported by some positive Bielschowsky Silver staining signal in the blood vessel wall. No plaque-like formations of positive Aβ1-42 aggregation with any of the dose could have been detected by immunohistochemistry at both time-points. Conclusions: Development of cerebral β-amyloid pathology in the STZ-icv rat model of sAD is a dose-dependent, non-acute effect which takes at least 3 months to be manifested in the form of angiopathy. Acknowledgement: Supported by the Unity Through Knowledge Fund (UKF 64-10) and MZOS.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1080003-0020
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Tiskani medij: da
Upisao u CROSBI: Melita Šalković-Petrišić (melitas@mef.hr), 20. Pro. 2013. u 09:48 sati



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