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Pregled bibliografske jedinice broj: 667007

Zbornik radova

Autori: Knapić, Marina; Knezović, Ana; Šimić, Goran; Šalković-Petrišić, Melita
Naslov: Hippocampal and cortical neuronal damage in the streptozotocin rat model of Alzheimer’s diseases
Izvornik: Clinical Neuropathology 31(4) / Ironside, James (ur.). - Edinburgh : British Neuropathological Society , 2012. 290-290.
Dio CC časopisa: DA
Skup: 10th European Congress of Neuropathology
Mjesto i datum: Edinburgh, Škotska, 06-09.06.2012.
Ključne riječi: hippocampus; streptozotocin; neuron damage
Sažetak:
Introduction: Morphological changes in the brain of the streptozotocin-intracerebroventricularly (STZ-icv) treated rat model of sporadic Alzheimer’s disease (sAD) have been investigated in much lesser extent than the behavioral and neurochemical ones. We have investigated the STZ-icv dose-dependency of rat cortical and hippocampal neuronal damage in the acute and chronic phase following the icv-treatment. Methods: Adult male Wistar rats were administered STZ (0.1, 1 and 3 mg/kg dose) or vehicle (controls) icv injections and sacrificed 1 week and 3 months afterwards. Paraffin-embedded brain sections of pre-mortally fixative perfused animals were analysed by Nissl staining in the parietal cortex (PC), hippocampal regions C1, C2 and dentate gyrus (DG). Positive signal was image analyzed and quantified by “CellSense Dimension”. Statistical significance was tested by Kruskal-Wallis followed by Mann Whitney U test, p<0.05. Results: Nissl staining revealed acute changes in the hippocampal regions only, manifested generally as 25% decrease in cell number in C1 and DG with the highest dose (p<0.05). Three months after the treatment, these values were normalized in comparison to the control, while slight tendency to decrease (-16%) has been found in the cell number in the PC region (p<0.05). Conclusions: These preliminary results suggest that neuronal damage seems to be manifested in the post-treatment- and region-dependent manner in the STZ-icv rat model of sAD, with no particular STZ-icv dose dependency. Acknowledgement: Supported by the Unity Through Knowledge Fund (UKF 64-10) and MZOS
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108-1080003-0020
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Tiskani medij: da
Upisao u CROSBI: Melita Šalković-Petrišić (melitas@mef.hr), 20. Pro. 2013. u 09:53 sati



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