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Characterizing the movement of different actin cytoskeleton mutants of Dictyostelium discoideum

Cell motility is of crucial importance for many physiological and pathological processes in multicellular organisms. The amoeboid protozoan Dictyostelium discoideum is a standard model organism used in cell motility research as well-suited for studying components of the actin cytoskeleton that are functionally conserved throughout the eukaryotic domain. Initial research of cell motility was based on the Brownian motion model describing random movement of small particles caused by thermic fluctuations. Over time, more precise measurements revealed intrinsic patterns in locomotion paths of eukaryotic cells, leading to modifications and extensions of the aforementioned model. The aim of this research is to characterize cell motility of different actin cytoskeleton mutants of D. discoideum within the framework of a generalized Langevin model extended with a memory term. Furthermore, we will subdivide cell populations belonging to single strains into subgroups based on motility characteristics of individual cells.

cell motility; Dictyostelium discoideum; actin cytoskeleton

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