Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies (CROSBI ID 200468)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Zoldoš, Vlatka ; Horvat, Tomislav ; Lauc, Gordan
engleski
Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies
Majority of eukaryotic proteins are glycosylated and their glycan moieties have numerous important structural, functional and regulatory roles. Because of structural complexity of glycans and technological limitations glycomics, and particularly glycoproteomics was not able to follow rapid progress in genomics and proteomics over last 30 years. However, the field of glycan has been progressing rapidly and first large-scale studies of the glycome have been completed recently. These studies have revealed significant differences in glycome composition between individuals, which may contribute to the human phenotypic variability. The current state-of-the-art in high-throughput glycomics and its integration with genomics, epigenomics and lipidomics is reviewed in this article.
Glycomics; Epigenomics; Genomics; Systems Biology
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Biologija