engleski

Placental growth factor in healthy, diabetic and IUGR pregnancies

Angiogenesis and vascular transformation are important processes in the normal development of the placenta. Placental growth factor (PlGF) is a potent angiogenic growth factor and is thought to be important for placental development. THE AIM OF THE STUDY was to analyse PlGF levels throughout gestation and difference between three studied groups. MATERIAL AND METHODS: Serum samples were collected from (1) 24 healthy pregnant women throughout normal gestation, (2) 39 diabetic pregnant women throughout gestation, and (3) 10 pregnant women with IUGR from 34 weeks of gestation. Placenta growth factor levels were determined with an immunoassay. RESULTS: PlGF levels during normal and diabetic pregnancy increased from the 6th week of gestation to the 30th week. From 30 weeks' gestation PlGF subsequently declined to delivery (Figure). It was not found statistically significant difference in PlGF levels between healthy (123.4ą65.2) and diabetic pregnancy (163.6ą103.1 mg/L) at the time of the term delivery. Significantly less PlGF was found in pregnancies complicated by IUGR (89, 8ą33, 4 mg/L) when compared with healthy and diabetic pregnancies (p<0, 05). It was not found statistically significant correlation between birthweight and maternal levels of PlGF. CONCLUSION: PlGF levels are increased from the beginning of pregnancy to the late of second trimester in the groups of healthy and diabetic pregnant women ; after 30 weeks of gestation they subsequently declined to delivery. PlGF levels are significantly decreased in the maternal circulation in cases of pregnancies with IUGR. PlGF does not have a direct effect on fetal growth.

placental growth factor; insulin dependent diabetes mellitus; placenta

Rad je kao predavaje prezentiran i na skupovima: a) 31st Annual Meeting of the European Association for the Study of Diabetes. Diabetic pregnancy study group, održanom od 22.-24.10.1999., Brijuni, Htvatska ; objavljen u Knjizi sažetaka ; b) 33rd Annual Meeting of the European association for the Study of Diabetes. Diabetic pregnancy study group, održanom od 13.-16.09.2001., Oxford, Engleska ; objavljen u Knjizi sazetaka, str. 53-53.