Type I diabetes (T1DM) is a common chronic disease characterized by selective autoimmune destruction of the pancreatic beta celles and subsequent dependence of endogenous insulin. While insulin resistance is a recognized hallmark of type 2 diabetes (T2DM) it also appears to play a significant role in the pathogenesis of T1DM and its vascular complications. Increased insulin resistance (IR) and Metabolic syndrome (MS) can be found in about 30%–40 % of T1DM patients depending on the used MS definition. The mechanisms of insulin resistance in T1DM are not well defined as in T2DM and the pathogenesis of IR and MS in T1DM has not been clarified. Data regarding the role of various factors related to IR and MS development are scarse. Because of its association with the development of diabetic complications lowering IR is likely to be important in T1DM patients.

Kliničke medicinske znanosti