engleski

The impact of FSH receptor gene polymorphism 2039G>A on controlled ovarian stimulation response in women undergoing in vitro fertilization

Single nucleotide polymorphism (SNP) 2039G>A (Asn680Ser) in the follicle stimulating hormone receptor gene (FSHR) has been related to the women’s response to the controlled ovarian stimulation (COS), which is one of the key factors for the successful in vitro fertilization. To assess the potential of this SNP for predicting ovarian response to FSH stimulation, 211 women undergoing IVF were genotyped. In addition to the hormonal status determination (the basal concentrations of FSH, luteinizing hormone (LH), estradiol (E2), thyroid-stimulating hormone (TSH) and prolactin), the number of antral follicles was estimated, as well. It was found that genotype 2039G/A (Asn680/Ser680) of FSHR is neither a good predictor of ovarian reserve nor of ovarian response upon controlled FSH stimulation. Consequently, the genotyping of SNP 2039G>A of FSHR for identifying poor FSH responders following controlled ovarian stimulation (COS) is not diagnostically valuable. Yet, women of younger age (< 32 years) (63 women), who were carriers of the homozygous form (2039A/A, Ser680/Ser680) (16 women), previously related to the poor ovarian response, had significantly higher number of oocytes (comparing to other genotypes of the same age, and also to the same genotype of different age ; p < 0.01). Consequently, they were recognized as predisposed for hyper-response upon FSH controlled stimulation. Thus, genotyping for this FSHR SNP 2039G/A seems to be a promising biomarker for pre-identifying women who should be treated with lower FSH dosage during IVF. Further studies are required to assess the role of this polymorphism, including additional alleles, in FSH hypersensitivity reactions in women undergoing IVF procedures.

FSHR receptor gene; SNP 2039G>A; controlled ovarian stimulation; in vitro fertilization

nije evidentirano