engleski

Selective advantage of S-layer surface proteins presence in Lactobacillus probiotic strains

Bacterial surface (S-) S-layers are macromolecular paracrystalline arrays covering cell envelope which are composed of identical protein or glycoprotein subunits. So far, among numerous lactic acid bacteria (LAB) species these proteins have been identified only between several Lactobacillus members. The S-layer proteins of Lactobacillus strains have specific features and their biological roles have not yet been fully elucidated. Although these surface proteins are yet to be characterised, several functional roles in Lactobacillus cells have been proposed. In fact, some probiotic properties of Lactobacillus bacteria, such as adhesion, pathogens exclusion and immunomodulation have been related with the occurrence of S-layers. Hence, in this manuscript the most recent studies together with the results obtained in PhD. Jagoda Šušković, Prof. research group, concerning S-layer protein characterisation are summarised. Especially the functional role of S-layer protein in important probiotic traits, adhesion to intestinal epithelial cells, immunomodulation activity and in competitive exclusion of pathogens by Lactobacillus strains, is discussed.

functionality; Lactobacillus; probiotic; S-layer surface proteins

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