engleski

Nine-year Registry of Native Renal Biopsy at Department of Pathology, Dubrava University Hospital in Zagreb

The aim of the study was to assess the incidence of native renal diseases diagnosed by biopsy at Department of Pathology, Dubrava University Hospital. Renal biopsy registry kept at the Department was reviewed over a nine-year period (from April 2003 to December 2012), with retrospective statistical analysis of data on native renal diseases. During the study period, a total of 1981 native renal biopsies were performed, with patient age range 1-88 (mean 47.1) years. Biopsies originated from 11 Croatian hospitals and Mostar University Hospital (Bosnia and Herzegovina). Men had 1.3 times more biopsies than women (M:F=1085:806). Glomerular diseases were the most frequent diagnosis (70.9%), followed by diseases of the blood vessels (8.8%) and tubular interstitium (5.0%). Primary glomerular diseases were 1.4 times more frequent than secondary ones. IgA nephropathy was the most common disease diagnosed in 18.9% of biopsies, followed by focal segmental glomerulosclerosis (12.1%) and membranous glomerulonephritis (8.4%). Pauci-immune glomerulonephritis was the most common secondary glomerular disease in our sample (6.9%), followed by lupus nephritis (5.6%) and diabetic nephropathy (5.5%). Normal renal parenchyma was found in 3.7% of biopsies. End stage renal disease of unknown cause was found in 0.8% of biopsies. Some diseases were more frequently diagnosed in women than in men and vice versa. IgA nephropathy was 2.7 times (M:F=263:96), diabetic nephropathy 2.4 times (M:F=73:31) and FSGS 1.9 times more frequently diagnosed in men than in women. Lupus nephritis was 2.8 times more frequently diagnosed in women than in men (F:M=78:28). In conclusion, currently two-thirds of renal biopsies performed in Croatia are processed by our laboratory. We believe that the data presented are representative and provide detailed information on the incidence, prevalence and trends in the epidemiology of renal diseases in Croatia.

Renal biopsy; registry

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