engleski

Systems biology and biotechnology

Systems biology in present genome era receives the most important position in modern “genome based biotechnology”. Its importance is result of exceptional development of experimental high-throughput techniques which deliver high dimensional multivariate data in a single biological experiment. Availability of large data sets are sources of biologically es-sential information on a system level which can be only inferred by mathematical systems theory concepts and application of mathematical/statistical methods and bioinformatics tools. The integration of information derived from a genome of industrially important microorgan-isms and bioprocess engineering has led to the new generation of “genome based biotechnol-ogy”. Applications are very diverse, from the fundamental research in biology to applicative fields such as medicine, ecology, and most importantly in industrial biotechnology. Here is given a short review of the basic concept of the biological systems theory from a view point of biochemical engineering with the aims of white (energy production) and red (pharmaceuti-cal production). Case studies are presented results of the system flux control analysis of E. coli glycolysis and the S. cerevisiae pathways for ergosterol and sphingolipid synthesis.

systems analysis; metabolic networks; global sensitivity; CellDesignerTM

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