Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Genotyping of CYP2D6 in Parkinson's Disease (CROSBI ID 92382)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Štefanović, Mario ; Topić, Elizabeta ; Ivanišević, Ana-Maria ; Relja, Maja ; Koršić, Marta Genotyping of CYP2D6 in Parkinson's Disease // Clinical chemistry and laboratory medicine, 38 (2000), 9; 929-934. doi: 10.1515/CCLM.2000.136

Podaci o odgovornosti

Štefanović, Mario ; Topić, Elizabeta ; Ivanišević, Ana-Maria ; Relja, Maja ; Koršić, Marta

engleski

Genotyping of CYP2D6 in Parkinson's Disease

Parkinson's disease is characterized by progressive degeneration of DA neurons. Cytochrome P450 enzyme is one of the most investigated and highly polymorphic isoforms, which metabolizes many drugs and is also involved in the metabolism of dopamine. Using allele-specific multiplex PCR, we genetyped 186 subjects for CYP2D6 *3, *4, *6, *7, and +( alleles in order to esrtimate allelic, genotyping and predicted phenotype frequencies in the control and patient groups, and to investigate the possible statistical differences between PD disease patients (n=41) and healthy controls (n=145). PD patients were further divided into two subroups according to H&Y staging of the disease (HY).The preliminary results of this study showed that only the prevalence of CYP2D6 *4 allele differed significantly between the PD patients and control groups.

Parkinson's Disease; CYP2D6; clinical oscilation

Rad je kao poster prezentiran na skupu 1st Alps-Adria meeting on human genetics, održanom od 14.-15.04.2000.g., Brijuni, Hrvatska ; objavljen u Knjizi sažetaka ; Ljiljana Zergollern (ur.) ; Zagreb : Hrvatsko društvo za humanu genetiku, 2000. ; str. 53-54.

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

38 (9)

2000.

929-934

objavljeno

1434-6621

10.1515/CCLM.2000.136

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Poveznice
Indeksiranost