Drug-Induced Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopaty (CROSBI ID 203111)
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Sepčić, Juraj ; Bučuk, Mira ; Perković, Olivio ; Šepić-Grahovac, Dubravka ; Trošelj Vukić, Biserka ; Poljak, Ivica ; Crnić-Martinović, Marija ; Turel, Iztok ; Ristić, Smiljana ; Sepčić, Kristina
engleski
Drug-Induced Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopaty
We report clinically rare and serious adverse reactions that occurred after the co-administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterials, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
ranitidine; ibuprofen; ciprofloxacin; drug interactions; aseptic meningitis; deafness
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nije evidentirano
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti