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Chromosome Studies in Patients with a Defective Reproductive Fitness (CROSBI ID 480833)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Radojčić Badovinac, Anđelka ; Buretić-Tomljanović, Alena ; Starčević, Nada ; Kapović, Miljenko ; Vlastelić, Ivica ; Randić, Ljiljana Chromosome Studies in Patients with a Defective Reproductive Fitness // European Meeting of Immunology and Reproduction Joint meeting with the 5th Congress of the Alps Adria Society of Immunology of Reproduction : Abstracts Book / Lenzi, Andrea (ur.). Rim: ASSIR, 1999. str. 46-46

Podaci o odgovornosti

Radojčić Badovinac, Anđelka ; Buretić-Tomljanović, Alena ; Starčević, Nada ; Kapović, Miljenko ; Vlastelić, Ivica ; Randić, Ljiljana

engleski

Chromosome Studies in Patients with a Defective Reproductive Fitness

The mutant genes and chromosomal disorders can act to disturb gamete formation and to impair normal embryonic development. It is obvious, that besides the aneuploid segregation do to parental chromosomal aberration, a post-zygotic factor leads to uncontrolled chromosome distribution in early cleavage stage. In order to investigate aetiology of the infertility in our population and to assess the chromosomal component in a group of infertile couples and individuals with fertility problems, 783 persons (259 couples, 158 male and 106 female with different clinical diagnoses of sterility and infertility, were analysed cytogeneticaly. Overall frequency of mayor chromosomal aberration is 13.1 % (103/783). Reported frequency in general population is less than 1%, what suggests that fertility or sterility problems are one of the most certain symptoms for the chromosomal aberration. A cause for the repeated spontaneous aberration and/or malformed child and sterility problems in 18.0% (47/259) couples is also chromosome abnormality. Chromosomal disorder in couples seeking IVF and ICSI is considerable, (22.2% - 8/38 couples) especially minor mosaicism of sex chromosomes in the female partners. Incidence of chromosome abnormalities in group of infertile men is also increased -17.7% (28/158), and within subfertile female group is 26.4% (28/106), a figure significantly different from control frequency of 0.4 % for women in general. Investigations are supported by grant #062008 of the Croatian Ministry of Science.

Chromosomal aberration; fertility apontaneous abortions; sterility

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Podaci o prilogu

46-46.

1999.

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objavljeno

Podaci o matičnoj publikaciji

European Meeting of Immunology and Reproduction Joint meeting with the 5th Congress of the Alps Adria Society of Immunology of Reproduction : Abstracts Book

Lenzi, Andrea

Rim: ASSIR

Podaci o skupu

European Meeting of Immunology and Reproduction Joint meeting with the Congress of the Alps Adria Society of Immunology of Reproduction (5 ; 1999)

predavanje

28.10.1999-29.10.1999

Rim, Italija

Povezanost rada

Javno zdravstvo i zdravstvena zaštita