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Human papillomavirus status in extragenital nonmelanoma skin cancers (CROSBI ID 204426)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Ledić Drvar, Daniela ; Lipozenčić, Jasna ; Sabol, Ivan ; Bukvić Mokos, Zrinka ; Ilić, Ivana ; Grce, Magdalena Human papillomavirus status in extragenital nonmelanoma skin cancers // Clinics in dermatology, 32 (2014), 2; 248-252. doi: 10.1016/j.clindermatol.2013.08.009

Podaci o odgovornosti

Ledić Drvar, Daniela ; Lipozenčić, Jasna ; Sabol, Ivan ; Bukvić Mokos, Zrinka ; Ilić, Ivana ; Grce, Magdalena

engleski

Human papillomavirus status in extragenital nonmelanoma skin cancers

About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs) ; namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common malignancies in Caucasians. In fact, there is an intense connection between sunlight exposure, fair skin, HPV, and development of NMSC. We have conducted a pilot study that included tissue samples from 26 carcinoma patients, of which there were 13 BCC and 13 SCC. HPV detection and typing was done with DNA amplification and sequencing, respectively. In total, 23.1% of SCC samples (3/13) and 7.7% of BCC samples (1/13) were positive for HPV DNA. The importance of understanding all aspects of NMSC carcinogenesis may be to reveal novel therapeutic options or preventive measures for HPV containing NMSC patients.

Human papillomavirus; basal cell carcinoma; squamous cell carcinoma

S.I.: Update on Sexually Transmitted Infections ; Jasna Lipozenčić (ur.).

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Podaci o izdanju

32 (2)

2014.

248-252

objavljeno

0738-081X

10.1016/j.clindermatol.2013.08.009

Povezanost rada

Kliničke medicinske znanosti

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