Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Telomere Q-PNA-FISH - Reliable Results from Stochastic Signals (CROSBI ID 205234)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ćukušić Kalajzić, Andrea ; Škrobot Vidaček, Nikolina ; Huzak, Miljenko ; Ivanković, Milena ; Rubelj, Ivica Telomere Q-PNA-FISH - Reliable Results from Stochastic Signals // PLoS One, 9 (2014), e92559-x. doi: 10.1371/journal.pone.0092559

Podaci o odgovornosti

Ćukušić Kalajzić, Andrea ; Škrobot Vidaček, Nikolina ; Huzak, Miljenko ; Ivanković, Milena ; Rubelj, Ivica

engleski

Telomere Q-PNA-FISH - Reliable Results from Stochastic Signals

Structural and functional analysis of telomeres is very important for understanding basic biological functions such as genome stability, cell growth control, senescence and aging. Recently, serious concerns have been raised regarding the reliability of current telomere measurement methods such as Southern blot and quantitative polymerase chain reaction. Since telomere length is associated with age related pathologies, including cardiovascular disease and cancer, both at the individual and population level, accurate interpretation of measured results is a necessity. The telomere Q-PNA-FISH technique has been widely used in these studies as well as in commercial analysis for the general population. A hallmark of telomere Q-PNA-FISH is the wide variation among telomere signals which has a major impact on obtained results. In the present study we introduce a specific mathematical and statistical analysis of sister telomere signals during cell culture senescence which enabled us to identify high regularity in their variations. This phenomenon explains the reproducibility of results observed in numerous telomere studies when the Q-PNA-FISH technique is used. In addition, we discuss the molecular mechanisms which probably underlie the observed telomere behavior.

Telomeres; Q-PNA-FISH

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

9

2014.

e92559-x

objavljeno

1932-6203

10.1371/journal.pone.0092559

Povezanost rada

Matematika, Biologija

Poveznice
Indeksiranost