Antidotal efficacy of quinuclidinium oximes against soman poisoning (CROSBI ID 79126)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Lucić, Ana ; Radić, Božica ; Peraica, Maja ; Mesić, Milan ; Primožič, Ines ; Binenfeld, Zlatko
engleski
Antidotal efficacy of quinuclidinium oximes against soman poisoning
The efficacy of newly synthesized quinuclidinium oximes was tested in vitro and in vivo. For this purpose the inhibitory power of oximes (IC50), acute toxicity (LD50) as well as reactivating and protective capacities with respect to soman-inhibited acetylcholinesterase of human erytrocytes, were determined for each of the oximes. All oximes tested were ineffective in vitro but protected mice very efficiently (BM-1 protects against 4 LD50 of soman). The results indicate that the in vivo effectiveness of quinuclidinium oximes against soman poisoning may not be related to reactivation or protection of AChe but rather to some other mechanism of the cholinergic system.
Quinuclidinium oximes; Soman; Acetylcholinesterase reactivators
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Podaci o izdanju
Povezanost rada
Kemija, Kliničke medicinske znanosti