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Antidotal efficacy of quinuclidinium oximes against soman poisoning (CROSBI ID 79126)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lucić, Ana ; Radić, Božica ; Peraica, Maja ; Mesić, Milan ; Primožič, Ines ; Binenfeld, Zlatko Antidotal efficacy of quinuclidinium oximes against soman poisoning // Archives of toxicology, 71 (1997), 7; 467-470-x

Podaci o odgovornosti

Lucić, Ana ; Radić, Božica ; Peraica, Maja ; Mesić, Milan ; Primožič, Ines ; Binenfeld, Zlatko

engleski

Antidotal efficacy of quinuclidinium oximes against soman poisoning

The efficacy of newly synthesized quinuclidinium oximes was tested in vitro and in vivo. For this purpose the inhibitory power of oximes (IC50), acute toxicity (LD50) as well as reactivating and protective capacities with respect to soman-inhibited acetylcholinesterase of human erytrocytes, were determined for each of the oximes. All oximes tested were ineffective in vitro but protected mice very efficiently (BM-1 protects against 4 LD50 of soman). The results indicate that the in vivo effectiveness of quinuclidinium oximes against soman poisoning may not be related to reactivation or protection of AChe but rather to some other mechanism of the cholinergic system.

Quinuclidinium oximes; Soman; Acetylcholinesterase reactivators

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Podaci o izdanju

71 (7)

1997.

467-470-x

objavljeno

0340-5761

Povezanost rada

Kemija, Kliničke medicinske znanosti

Indeksiranost