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Photochemical synthesis of medium and large aza-heterocyclic compounds with potential biological activity (CROSBI ID 610526)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Mandić, Leo ; Mlinarić-Majerski, Kata ; Basarić, Nikola Photochemical synthesis of medium and large aza-heterocyclic compounds with potential biological activity // MACROCYCLES - synthesis, medicinal chemistry and biological activity. Zagreb, 2014

Podaci o odgovornosti

Mandić, Leo ; Mlinarić-Majerski, Kata ; Basarić, Nikola

engleski

Photochemical synthesis of medium and large aza-heterocyclic compounds with potential biological activity

Various aza-heterocyclic compounds show biological activity. For example, pyrrolo[1, 4]benzodiazepines show highly selective binding to DNA.1 Likewise, benzazepine skeleton is a part of numerous biologically active compounds.2 Furthermore, adamantane is a very important pharmacophore that has been found in different classes of biologically active compounds.3 Therefore, it is necessary to develop new synthetic methods for the preparation of new functionalized adamantyl-heterocyclic derivatives. With the ongoing interest in our group to apply photochemical approach to the synthesis of adamantyl-heterocyclic derivatives with biological applications, 4 we have functionalized adamantanes by the phthalimide group, versatile chromophore that undergoes various photochemical reactions. Herein we describe synthesis of novel (N-phthalimido)adamantane carboxylic acid 1 and its efficient one-pot transformation to complex heterocyclic compound, adamantyl benzazepine 2, with anticipated biological activity, that is yet to be tested.

adamantanes; benzazepines; photochemistry; biological activity

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Podaci o prilogu

2014.

objavljeno

Podaci o matičnoj publikaciji

MACROCYCLES - synthesis, medicinal chemistry and biological activity

Zagreb:

Podaci o skupu

Macrocycles: synthesis, medicinal chemistry and biological activity

poster

28.04.2014-29.04.2014

Zagreb, Hrvatska

Povezanost rada

Kemija

Poveznice