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Expression of bone morphogenetic proteins in long-term culture of human bone marrow stromal cells (CROSBI ID 481066)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Kisić, Veronika ; Mazić, Sanja ; Bašić, Nikolina ; Martinović, Snježana ; Batinić, Drago ; Labar, Boris ; Vukičević, Slobodan Expression of bone morphogenetic proteins in long-term culture of human bone marrow stromal cells // Calcified tissue international. Supplement. 2000. str. 92-92

Podaci o odgovornosti

Kisić, Veronika ; Mazić, Sanja ; Bašić, Nikolina ; Martinović, Snježana ; Batinić, Drago ; Labar, Boris ; Vukičević, Slobodan

engleski

Expression of bone morphogenetic proteins in long-term culture of human bone marrow stromal cells

BMP are expressed in bone marrow stromal cells and involved in regulation oh hematopoiesis. The aim of this investigation was to explore expression of bone morphogenetic proteins, their receptors and BMP second messengers in long- term culture of human bone marrow stromal cells. Hematopoietic activity was present throughout the investigation period. RNA was isolated from cultivated cells using a TRIzol reagent ; cDNA was then synthesized and RT-PCR performed using primers for BMP-2 to 7, ALK-2, 3 and 6 and Smad-1, 4 and 5. The results indicate that bone marrow stromal cells produce mRNA for ALK-2 and 6, Smad-1, 4 and 5, and both mRNA and protein BMP-3, 4 and 7. Since hematopoietic cells have BMP receptors, a paracrine mechanism in regulating hematopoiesis is suggested.

BMP; marrow stromal cells; hematopoiesis; long- term culture of human bone marrow stromal cells

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Podaci o prilogu

92-92.

2000.

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objavljeno

Podaci o matičnoj publikaciji

Calcified tissue international. Supplement

0944-0747

Podaci o skupu

European Symposium on Calcified Tissue (27 ; 2000)

poster

05.05.2000-10.05.2000

Tampere, Finska

Povezanost rada

Kliničke medicinske znanosti