Nonaromatic naphthalan for the treatment of oral mucosal diseases (CROSBI ID 610935)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Andabak Rogulj, Ana ; Alajbeg, Ivan ; Džanić, Emir
engleski
Nonaromatic naphthalan for the treatment of oral mucosal diseases
Objectives: Nonaromatic naphthalan (NAVS) is a purified natural oil derivative, abundant in steranes (geogenic „steroids“). The purpose of this study is to evaluate the effectiveness of NAVS in the treatment of oral mucosal diseases (oral lichen planus (OLP), recurrent aphthous ulcerations (RAU) and cicatricial pemphigoid (CP)). Methods: We applied NAVS oil in adhesive paste in patients with clinically and histologically proven OLP, in patients with RAU (double blind randomized ; topical betamethasone in adhesive paste used as control), and in 1 subject with CP (open label), three times daily during 4 weeks. The severity of the OLP lesions was objectively scored. The number and diameter of RAU lesions were also assessed on days 3 and 5. The intensity of pain and discomfort was determined using visual analog scale (VAS) and „Oral health impact profile“(OHIP-14) before and after therapy. Statistical analysis was performed by use of Wilcoxon test for paired samples to evaluate the effect of treatment in each group. Treatment effect between the groups was performed by Mann-Whitney test ; p values lower than 0.05 were considered significant. Results: The results of this study showed that NAVS has successfully reduced the clinical signs and symptoms of OLP ; has reduced the number, diameter and symptoms in patients with RAU statistically comparable with corticosteroids. NAVS has reduced clinical signs in 1 CP patient. Conclusion: These results indicate the good performance of NAVS as a potential alternative to corticosteroids in treatment of oral mucosal diseases.
nonaromatic naphthalan ; treatment ; oral mucosal diseases
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Podaci o prilogu
e382-e382.
2014.
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objavljeno
10.1016/j.oooo.2014.01.192
Podaci o matičnoj publikaciji
Oral surgery, oral medicine, oral pathology and oral radiology
2212-4403
2212-4411
Podaci o skupu
Frontiers in Oral medicine, 2014
poster
09.04.2014-12.04.2014
Orlando (FL), Sjedinjene Američke Države