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Function of circle of Willis (CROSBI ID 206356)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Vrselja, Zvonimir ; Brkić, Hrvoje ; Mrđenović, Stefan ; Radić, Radivoje ; Ćurić, Goran Function of circle of Willis // Journal of cerebral blood flow and metabolism, 34 (2014), 4; 578-584. doi: 10.1038/jcbfm.2014.7

Podaci o odgovornosti

Vrselja, Zvonimir ; Brkić, Hrvoje ; Mrđenović, Stefan ; Radić, Radivoje ; Ćurić, Goran

engleski

Function of circle of Willis

Nearly 400 years ago, Thomas Willis described the arterial ring at the base of the brain (the circle of Willis, CW) and recognized it as a compensatory system in the case of arterial occlusion. This theory is still accepted. We present several arguments that via negativa should discard the compensatory theory. (1) Current theory is anthropocentric ; it ignores other species and their analog structures. (2) Arterial pathologies are diseases of old age, appearing after gene propagation. (3) According to the current theory, evolution has foresight. (4) Its commonness among animals indicates that it is probably a convergent evolutionary structure. (5) It was observed that communicating arteries are too small for effective blood flow, and (6) missing or hypoplastic in the majority of the population. We infer that CW, under physiologic conditions, serves as a passive pressure dissipating system ; without considerable blood flow, pressure is transferred from the high to low pressure end, the latter being another arterial component of CW. Pressure gradient exists because pulse wave and blood flow arrive into the skull through different cerebral arteries asynchronously, due to arterial tree asymmetry. Therefore, CW and its communicating arteries protect cerebral artery and blood brain barrier from hemodynamic stress.

atherosclerosis; cerebrovascular disease; comparative anatomy; evolution; pulse wave analysis; redundancy

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Podaci o izdanju

34 (4)

2014.

578-584

objavljeno

0271-678X

10.1038/jcbfm.2014.7

Povezanost rada

Temeljne medicinske znanosti, Biologija

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