Conformational properties of ferrocene peptides containing exchanged sequence of constituent amino acids (CROSBI ID 611434)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Barišić, Lidija ; Kovačević, Monika ; Mamić, Marija ; Kodrin, Ivan ; Mihalić, Zlatko ; Rapić, Vladimir
engleski
Conformational properties of ferrocene peptides containing exchanged sequence of constituent amino acids
We explored the structural properties of ferrocene peptides II [Y-AA-Fca-OMe ; Y = Boc, Ac ; AA = L-Ala, D-Ala ; Fca = 1'-aminoferrocene-1-carboxylic acid] [1] with an exchanged sequence of constituent amino acids relative to previously described I (Y-Fca-AA-OMe ; Y = Boc, Ac ; AA = L-Ala, D-Ala) [2]. In order to examine their conformational properties, peptides II were subjected to spectroscopic analysis (IR, 1H NMR, CD) and molecular modeling (DFT). The alteration of peptides I into II significantly influenced their conformational properties. Conjugates I were stabilized through interchain hydrogen bonding, whereas inter- and intrachain hydrogen bonds were established in their constitutional isomers II. The replacement of the bulky Boc group with an Ac group did not cause major conformational changes, and the absolute configuration of the alanine chiral centers did not affect the conformational properties.
Ferrocene; peptide; conformational analysis
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Podaci o prilogu
169-169.
2013.
objavljeno
Podaci o matičnoj publikaciji
Hadžiev, Andrea ; Blažeković, Zdenko
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
Podaci o skupu
XXIII. Hrvatski skup kemičara i kemijskih inženjera
poster
21.04.2013-24.04.2013
Zagreb, Hrvatska