engleski

The influence of age on bone metabolism in mares during late pregnancy and lactation

To investigate the influence of age on bone metabolism in mares, the concentrations of carboxyterminal crosslinked telopeptide of type I collagen (CTx), osteocalcin (OCN) and parathyroid hormone (PTH) and insulin-like growth factor (IGF- I) were measured in blood serum of two age groups of mares during late pregnancy (70-50 days before foaling), during early lactation and at the peak of lactation (10-30 and 55-80 days after foaling, respectively). During late pregnancy, the concentration of PTH was significantly higher in older animals (8 to 19 years old), compared to younger animals (3.5 to 4 years old) (P<0.05). The concentration of OCN during late pregnancy was higher in younger, in comparison with older animals (P<0.05). The concentration of IGF- was significantly higher in the younger group during early lactation, in comparison to late pregnancy and the peak of lactation (P<0.05). Concentration of IGF-I did not differ between two age groups of mares. The results indicate on the differences in adaptation of bone metabolism to late pregnancy and lactation in older, in comparison to younger animals, reflected by elevated PTH secretion. Changes in concentration of serum IGF-I were not in correlation to bone metabolic parameters and were more prominent in younger animals.

bone remodelling markers; mares; pregnancy; lactation; age

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