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Micronucleus, alkaline, and human 8-oxoguanine glycosylase 1 modified comet assays evaluation of glass-ionomer cements - in vitro (CROSBI ID 206524)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Galić, Elizabeta ; Tadin, Antonija ; Galić, Nada ; Kašuba, Vilena ; Mladinić, Marin ; Rozgaj, Ružica ; Biočina-Lukenda, Dolores ; Galić, Ivan ; Želježić, Davor Micronucleus, alkaline, and human 8-oxoguanine glycosylase 1 modified comet assays evaluation of glass-ionomer cements - in vitro // Arhiv za higijenu rada i toksikologiju, 65 (2014), 2; 179-187. doi: 10.2478/10004-1254-65-2014-2392

Podaci o odgovornosti

Galić, Elizabeta ; Tadin, Antonija ; Galić, Nada ; Kašuba, Vilena ; Mladinić, Marin ; Rozgaj, Ružica ; Biočina-Lukenda, Dolores ; Galić, Ivan ; Želježić, Davor

engleski

Micronucleus, alkaline, and human 8-oxoguanine glycosylase 1 modified comet assays evaluation of glass-ionomer cements - in vitro

The purpose of this study was to evaluate the genotoxic potential of components leached from two conventional self-curing glass-ionomer cements (Fuji IX and Ketac Molar), and light-curing, resin modified glass-ionomer cements (Vitrebond, Fuji II LC). Evaluation was performed on human lymphocytes using alkaline and hOGG1 modified comet, and micronucleus assays. Each material, polymerised and unpolymerised, was eluted in extracellular saline (1 cm2 mL-1) for 1 h, 1 day, and 5 days. Cultures were treated with eluates using final dilutions of 10-2, 10-3, and 10-4. Alkaline comet assay did not detect changes in DNA migration of treated cells regardless of the ionomer tested, polymerisation state, and elution duration. Glass ionomers failed to significantly influence micronucleus frequency. No oxidative DNA damage in treated lymphocytes was observed using hOGG1 modified comet assay. Obtained results indicate high biocompatibility of all tested materials used in the study under experimental conditions.

biocompatibility ; cytotoxicity ; DNA damage ; genotoxicity ; lymphocytes

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Podaci o izdanju

65 (2)

2014.

179-187

objavljeno

0004-1254

1848-6312

10.2478/10004-1254-65-2014-2392

Povezanost rada

Dentalna medicina

Poveznice
Indeksiranost