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Revealing interactions between polyaza pyridinophane compounds and DNA/RNA polynucleotides by SERS spectroscopy (CROSBI ID 207891)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Dijanošić, Adriana ; Miljanić, Snežana ; Piantanida, Ivo ; Gonzales-Garcia, Jorge ; Garcia-Espana, Enrique Revealing interactions between polyaza pyridinophane compounds and DNA/RNA polynucleotides by SERS spectroscopy // Journal of Raman spectroscopy, 45 (2014), 10; 863-872. doi: 10.1002/jrs.4564

Podaci o odgovornosti

Dijanošić, Adriana ; Miljanić, Snežana ; Piantanida, Ivo ; Gonzales-Garcia, Jorge ; Garcia-Espana, Enrique

engleski

Revealing interactions between polyaza pyridinophane compounds and DNA/RNA polynucleotides by SERS spectroscopy

Surface-enhanced Raman scattering spectroscopy (SERS) in the near-infrared region had been applied to study interactions of polyaza pyridinophanes with single stranded RNA and double stranded DNA and RNA polynucleotides. Studied compounds, PYPOD and PHENPOD, differed in the central aromatic moiety, pyridine and phenanthroline, respectively, which linked two cyclic amines. An intense scattering was obtained from molecules adsorbed onto the silver nanoparticles, showing nonlinear concentration dependence in the 6.5x10-8-6.5x10-5 M range. New bands in spectra of PYPOD/polynucleotide and PHENPOD/polynucleotide mixtures were assigned to vibrational modes of polynucleotide moieties involved in interactions. SERS spectra of both polyaza pyridinophanes with single stranded RNA polynucleotides indicated hydrogen bonding between the small molecules and the nucleic bases of poly A, poly C and poly U, whereas an interaction of only PYPOD with poly G was suggested. SERS spectra implied that both compounds bound into the minor groove of the helical poly dAdT–poly dAdT polynucleotide, while none of polyaza pyridinophanes interacted with the grooves of the poly dGdC–poly dGdC polynucleotide. Nevertheless, intensity ratios suggested intercalation of the phenanthroline moiety of the PHENPOD molecules into the double helix of the guanine-cytosine polynucleotide. Spectral features also indicated binding of the PYPOD molecules within the major groove of the double stranded RNA analog.

surface-enhanced Raman scattering ; DNA/RNA polynucleotides ; polyaza pyridinophanes ; silver colloid

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Podaci o izdanju

45 (10)

2014.

863-872

objavljeno

0377-0486

10.1002/jrs.4564

Povezanost rada

Kemija

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