engleski

Epigenetic regulation of fetal brain development and neurocognitive outcome

Twenty-five years ago, the neurodevelopmental hypothesis of schizophrenia opened the way for analyzing potential prenatal influences on late postnatal pathogenetic events (1). Since that time, it has been well-established that hypoxia, infection, and other noxious factors can cause fetal brain injury and intrauterine growth restriction and that prenatal brain lesions can cause alterations in the postnatal brain development (2). A study in PNAS (3) suggests that even the subtle normal variations of intrauterine environment may lead to recognizable differences in postnatal brain structure and cognitive functions. Raznahan

schizophrenia; hypoxia; infection; fetal injury

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