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Pregled bibliografske jedinice broj: 712429

Časopis

Autori: Krušlin, Božo; Džombeta, Tihana; Bezjak, Miran; Sedmak, Goran; Petanjek, Zdravko; Šimić, Goran; Judaš, Miloš; Kostović, Ivica
Naslov: Congenital brain anomalies and chromosomal aberrations from the Zagreb Collection of human brains
Izvornik: Translational neuroscience (2081-3856) 5 (2014), 4; 293-301
Vrsta rada: pregledni rad
Ključne riječi: brain; collection; anomalies; Down syndrome; Patau syndrome; Edwards syndrome
Sažetak:
The Zagreb Collection of developing and adult human brains consists of approximately 1, 300 brains of fetuses, children and adults that were collected following routine autopsies in the period from 1974 to 2014. The collection comprises brains of different normal developmental stages that may serve for investigation of normal human brain development. Previous studies on this material have led to several important contributions on human cortical development, such as the discovery of the transient fetal subplate zone. The Zagreb Collection, however, also contains approximately 100 brains with different anomalies including chromosomal aberrations such as Down syndrome. We have analyzed all the available material from the Zagreb Collection and identified 44 brains of fetuses and children with Down syndrome, 10 with Patau syndrome, 6 with Edwards syndrome as well as 7 holoprosencephalic, 7 hydrocephalic and 4 microcephalic brains. The largest part of the Collection is available for further research using modern genetic, immunocytochemical and imaging methods, especially magnetic resonance imaging. Furthermore, the histological slides from the Zagreb Collection are currently being digitally scanned and made available as virtual slides to general scientific audience. The Zagreb Collection represents unique and versatile resource for the future study of normal and abnormal human brain development.
Projekt / tema: 108-1081870-1876, 108-1081870-1884
Izvorni jezik: ENG
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Scopus
Web of Science: Science Citation Index Expanded
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://link.springer.com/article/10.2478/s13380-014-0231-9
Broj citata:
Altmetric:
DOI: 10.2478/s13380-014-0231-9
URL cjelovitog teksta:
Google Scholar: Congenital brain anomalies and chromosomal aberrations from the Zagreb Collection of human brains
Upisao u CROSBI: Ivica Kostović (neuroan@mef.hr), 3. Ruj. 2014. u 12:21 sati



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