Inflammation and endothelial dysfunction in pathogenesis of diabetic retinopathy in patients with type 2 diabetes (CROSBI ID 613809)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Tomić, Martina ; Novak, Branko ; Ljubić, Spomenka
engleski
Inflammation and endothelial dysfunction in pathogenesis of diabetic retinopathy in patients with type 2 diabetes
The pathogenesis of diabetic retinopathy (DR) is insufficiently understood and presumed to possibly involve inflammation and endothelial dysfunction. The aim of the study was to investigate the relationship between inflammation markers, other markers of endothelial dysfunction and anthropometric parameters and their association with DR in patients with type 2 diabetes, divided into three groups: no retinopathy (n=65), mild/moderate nonproliferative (NPDR ; n=19) and severe NPDR/proliferative retinopathy (PDR ; n=23). The groups did not differ in the levels of inflammation markers, other markers of endothelial dysfunction and anthropometric parameters. C-reactive protein was correlated with fibrinogen, HbA1c, LDL-cholesterol, BMI, WC, WHR and C index. HbA1c was correlated with cholesterol, LDL-cholesterol, BMI and WC. Logistic regression analysis showed that diabetes duration and HbA1cmedian were the main predictors of retinopathy. The study demonstrated that the association between obesity, inflammation and other risk factors plays an important role in endothelial impairment involved in the pathogenesis of DR.
diabetic retinopathy; inflammation; endothelial dysfunction
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Podaci o prilogu
2013.
objavljeno
Podaci o matičnoj publikaciji
Diabetes - a Threat to Mankind ; 2013., B23
Podaci o skupu
Symposium on diabetes and its complications: Diabetes - a threat to mankind
poster
07.06.2013-08.06.2013
Helsinki, Finska