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Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma (CROSBI ID 208678)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Valković, Toni ; Babarović, Emina ; Lučin, Ksenija ; Štifter, Sanja ; Aralica, Merica ; Pećanić, Sanja ; Seili-Bekafigo, Irena ; Duletić-Načinović, Antica ; Nemet, Damir ; Jonjić, Nives Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma // BioMed research international, / (2014), 513170-1-513170-6. doi: 10.1155/2014/513170

Podaci o odgovornosti

Valković, Toni ; Babarović, Emina ; Lučin, Ksenija ; Štifter, Sanja ; Aralica, Merica ; Pećanić, Sanja ; Seili-Bekafigo, Irena ; Duletić-Načinović, Antica ; Nemet, Damir ; Jonjić, Nives

engleski

Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma

The aim of this pilot study was to determine the plasma levels of osteopontin (OPN) and vascular endothelial growth factor (VEGF) and find possible association between them and main clinical features and parameters of tumor burden in patient with multiple myeloma (MM). Plasma levels of OPN and VEGF were determined in 44 newly diagnosed MM patients and 24 healthy persons by ELISA method. These values were compared with the presence of anemia, renal dysfunction, and bone lesions as myeloma related clinical manifestations and with serum beta-2 microglobulin and Durie-Salmon clinical stage as prognosticators related to tumor mass. The value of OPN was significantly higher in MM patients with evident bone lesions (P = 0.03) and there was also a positive correlation with serum beta- 2 microglobulin (r = 0.366 ; P = 0.04). Furthermore, patients with lower Durie-Salmon stage had significantly lower OPN and VEGF levels (P = 0.05 ; P = 0.04, resp.). Our preliminary results found positive association between plasma level of OPN, tumor burden, and bone destruction. Further analysis should provide information about the possible use of OPN as useful clinical biomarker for monitoring bone disease and tumor mass, as well as a prognostic factor, or a possible target for pharmacological intervention.

Multiple myeloma ; osteopontin ; VEGF

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nije evidentirano

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Podaci o izdanju

/

2014.

513170-1-513170-6

objavljeno

2314-6133

10.1155/2014/513170

Povezanost rada

Kliničke medicinske znanosti

Poveznice
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