engleski

Mice lacking trefoil family factor 3 gene present with reduced rate of monounsaturated fatty acids in the liver

The aim of this study was to determine the rate of monounsaturated fatty acids (MUFAs) in the liver of Tff3 knock-out mice, as well as the serum glucose and lipid content. We found that: Tff3 knock-out mice compared to WT mice have significantly lower amount of MUFAs in the liver Total serum levels of the cholesterol, triglycerides, HDL or LDL cholesterol did not differ between WT and TFF3 defcient mice. Postprandial glucose levels in Tff3 knock-out mice were higher than in controls but did not reach statistical significance. Microscopic analysis of the liver sections revealed normal tissue architecture (HE) and glycogen reserves (PAS staining).

liver ; TFF3 ; glucose ; lipid

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