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Pregled bibliografske jedinice broj: 714815

Časopis

Autori: Zibar, Karin; Blaslov, Kristina; Bulum, Tomislav; Knežević-Ćuća, Jadranka; Smirčić Duvnjak, Lea
Naslov: Basal and postprandial change in serum fibroblast growth factor-21 concentration in type 1 diabetic mellitus and in healthy controls
Izvornik: Endocrine (Basingstoke) (1355-008X) 48 (2015), 3; 848-855
Vrsta rada: članak
Ključne riječi: Fibroblast growth factor-21; type 1 diabetes mellitus; C peptide negative; healthy controls
Sažetak:
Fibroblast growth factor-21 (FGF-21) appears to have an important role in glucose and lipid metabolism. FGF-21 secretion is mainly determined by nutritional status. The aim of this study was to measure basal and postprandial FGF-21 and postprandial change of FGF-21 concentration in type 1 diabetes mellitus (T1DM) patients and in healthy controls, and to investigate the differences between the groups. The cross-sectional study included 30 C-peptide negative T1DM patients, median age 37 years (20–59), disease duration 22 years (3–45), and nine healthy controls, median age 30 years (27–47). Basal and postprandial FGF-21 concentrations were measured by ELISA. The associations of FGF-21 with glucose, lipids, and insulin were analyzed. Individuals with T1DM showed significantly lower basal FGF-21 concentration (P = 0.046) when compared with healthy controls (median value 28.2 vs 104 pg/mL) and had significantly different postprandial change (∆ 30′−0′) of FGF-21 (P = 0.006) in comparison with healthy controls (median value −1.1 vs −20.5 pg/mL). The glucose and lipid status did not correlate with FGF-21. In healthy controls, postprandial insulin level correlated with basal FGF-21 (ρ = 0.7, P = 0.036). Multiple regression analysis showed that they are independently associated after adjustment for confounding factors (β = 1.824, P = 0.04). We describe the pathological pattern of basal and postprandial change of FGF-21 secretion not associated with glucose, lipid levels, or insulin therapy in patients with T1DM. Since FGF-21 has numerous protective metabolic effects in the experimental model, the lower basal FGF-21 concentration in T1DM patients opens the question about the potential role of recombinant FGF-21 therapy.
Projekt / tema: 045-1080230-0516
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
SCI-EXP, SSCI i/ili A&HCI
Current Contents Connect (CCC)
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
MEDLINE
Kategorija: Znanstveni
URL Internet adrese: http://link.springer.com/article/10.1007%2Fs12020-014-0413-9
Broj citata:
Altmetric:
DOI: 10.1007/s12020-014-0413-9
URL cjelovitog teksta:
Google Scholar: Basal and postprandial change in serum fibroblast growth factor-21 concentration in type 1 diabetic mellitus and in healthy controls
Upisao u CROSBI: Kristina Blaslov (kblaslov@gmail.com:kblaslov@student.mef.hr), 12. Ruj. 2014. u 17:48 sati



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