Comparison of the Impact of Four Generations of Progestins on Hemostatic Variables (CROSBI ID 208976)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Oslaković, Sandra ; Zadro, Renata
engleski
Comparison of the Impact of Four Generations of Progestins on Hemostatic Variables
This study was undertaken to evaluate the impact of progestins as part of low-estrogen (ethinyl estradiol [EE2] 35 mg) combined oral contraceptives (COCs) on hemostatic variables. One hundred ninety-five healthy women took oral contraceptives with following formulations: 35 EE2/norgestimate (NGM), 35 EE2/cyproterone acetate, 35 EE2/norethisterone, 30 EE2/levonorgestrel, 30 EE2/drospirenone (DRSP), 20 EE2/gestodene, and 20 EE2/DRSP, for 6 months. Hemostatic assays (prothrombin time, activated partial thromboplastin time, fibrinogen, resistance to activated protein C ratio, protein C, protein S, factor VIII [FVIII], antithrombin, plasminogen, a2-antiplasmin, inhibitor of plasminogen activator type 1 [PAI-1] and D-dimers) were performed in 3 time points: at baseline, after 3, and 6 cycles. For each formulation, results were compared according to baseline values, intergroup analysis, and the amount of estrogen or progestin component. Most of the variables were changed except FVIII. Significant difference between oral contraceptives was found in antithrombin, protein C, protein S activities, and PAI-1 values, but changes were mostly within reference range.
blood coagulation factors; clinical pharmacology; gynecology and obstetrics
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Podaci o izdanju
20 (4)
2014.
448-455
objavljeno
1076-0296
10.1177/1076029612463426
Povezanost rada
Temeljne medicinske znanosti