engleski

Dat scan examination-Benefit in clinical praxis

Dat Scan method in vivo evaluate degree of loss of dopaminergic neurons in striatum. It is neuroimage technique using radio-active substance 123 I-FP-CIT that selectively bound on cell transporting dopamin (dopamin transporter- DAT) in presinaptic terminal of dopaminergic neurons in striatum. We had analysed Dat Scan examined patients that were sent from our Department in period from 2006-2008. Patients were divided into the groups according to symptoms and according to different kind of tremors. Data were evaluated using χ2-test with the significance of p<0, 05. We analysed 55 patients in range from 20-78 years, average age 62 years. There were 33 female and 22 male patients. Patients were divided in regard to symptoms on those with tremor (54, 55%), those with extrapiramidal symptomatology (EPS) (36, 36%), with cerebellar symptoms (3, 64%) and patients with other symptoms (5, 45%). Dat Scan examination was normal in 54, 55% patients, and pathological in 45, 45% of patients. EPS had 70% of patients with pathological finding and 30% of patients with normal finding. Tremor was present in 33, 30% of patients with pathological finding, and 66, 67% patients with normal finding. Cerebellar signs were equally present in those with pathological and normal finding (50%), and other symptoms were present only in group of the patients with normal finding (100%). There was statistical significance p=0, 027. Dat Scan was pathological in 63, 33% and normal in 66, 67% of patients, and in the group with postural tremor finding was pathological in 25% and normal in 75% of patients. There was statistical significance p=0, 032. Patients having tremor as only symptom most often had normal Dat Scan, while patients having EPS most often had pathological finding. Patients with rest tremor had most often pathological Dat Scan, while patients with action and postural tremor had most often normal finding. Dat Scan examination is not only useful in differential between Parkinson's disease(including Parkinson Plus syndrom) and other kind of tremor, but also in it's earlier detection and treatment onset.

Dat Scan; Parkinson

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