Dynein, microtubule and cargo: a ménage à trois (CROSBI ID 209132)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Pavin, Nenad ; Tolić‑Nørrelykke, Iva M.
engleski
Dynein, microtubule and cargo: a ménage à trois
To exert forces, motor proteins bind with one end to cytoskeletal filaments, such as microtubules and actin, and with the other end to the cell cortex, a vesicle or another motor. A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners. In the present review, we focus on cytoplasmic dynein, which is required for a myriad of cellular functions in interphase, mitosis and meiosis, ranging from transport of organelles and functioning of the mitotic spindle to chromosome movements in meiotic prophase. We discuss how dynein targets sites where it can exert a pulling force on the microtubule to transport cargo inside the cell.
cargo ; cortical anchor ; dynein ; microtubule ; motor protein ; targeting
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