engleski

Index for serum globulin compensation in diffuse large B cell non Hodgkin lymphoma

Background. Low level of serum albumin have been used as prognostic factor for many malignant and other chronic diseases. Usually the decrease may be partly compensated by globular proteins but in some patients the failure of globulins to compensate may reflect advanced disease. Aim. We examined the prognostic value of globulin compensation index in patients with diffuse large B-cell non Hodgkin lymphoma (DLBCL). Methods. In Clinical Hospital Center of Rijeka, Croatia, 108 patients with DLBCL were analysed according the globulin compensation index (GCI) and other clinical and laboratory parameters. The GCI was determined using mathematical formula as described previously (F S Al-Joudy, Singapore Med J 2005 ; 46(12):710). According to literature patients were classified into three categories: 1.negative GCI and negative compensation ; 2.GCI of 0 to less than 1.0 with partial compensation and 3. GCI equal or greater than 1.0 with full compensation. Results. Negative GCI in patients with DLBCL showed a significant association with stage III/IV, > or =2 extranodal involvements and risk of high international prognostic index (P<0.05). The complete response (CR) rate (85.9%) in the full compensation (elevated GCI) was higher than in the negative or partial compensation (21.5%). The time to progression and overall survival were shorter in the group with negative GCI (P<0.05). Summary/Conclusions. GCI might be useful marker to indicate the extent of lymphoma involvement and prognosis in DLBCL patients.

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