Influence of vehicle type on the texture and release properties of liposomes-in-vehicle formulations (CROSBI ID 615563)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Palac, Zora ; Hurler, Julia ; Škalko-Basnet, Nataša ; Filipović-Grčić, Jelena ; Vanić, željka
engleski
Influence of vehicle type on the texture and release properties of liposomes-in-vehicle formulations
The aim of the present study was to assess different liposomes-in-vehicle formulations in respect to drug release and formulation properties. Deformable (DL), propylene glycol (PGL) and conventional liposomes (CL) were prepared by the film hydration method, followed by extrusion. Each of the liposome suspension, containing only liposomally-entrapped hydrophilic model drug diclofenac sodium (DCS), was mixed into the following vehicles: hydrogel, cream base or derma membrane structure base cream classic (DMS base) (10% w/w, liposome suspension/vehicle). The results of the release study confirm slower release of the drug from all of the liposomes-in-vehicle formulations as compared to the control.The slowest release of DCS was observed for the cream base, followed by the hydrogel and DMS base. A comparison of the drug-release profiles from different types of liposomes incorporated in hydrogel or cream base confirmed the slowest drug release from CL, whereas the drug release from PGL and DL was significantly faster (p<0.05). The assessed texture characteristics were significantly different between all of the examined vehicles. The cream base showed the highest values of all of the parameters assessed, followed by the hydrogel and DMS base. Mixing the liposomes in the cream base lowered the initial hardness by approximately 30% for the CL and PGL and slightly more for the DL (35%). Based on performed studies, propylene glycol liposomes-in-hydrogel seems to be the most suitable formulation for improving skin delivery of hydrophilic drug.
Liposomes; Deformable liposomes; Propylene glycol; Vehicle; Texture
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Podaci o prilogu
2014.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
10th Central European Symposium on Pharmaceutical Technology
poster
18.09.2014-20.09.2014
Portorož, Slovenija