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Metabolic control analysis (MCA) of the BTEX bioremediation model (CROSBI ID 615979)

Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija

Jurinjak Tušek, Ana ; Jurina, Tamara ; Čurlin, Mirjana ; Kurtanjek, Želimir Metabolic control analysis (MCA) of the BTEX bioremediation model // Proceedings of the 8th International Congress of Food Technologists, Biotechnologists and Nutritionists / Frece, Jadranka (ur.). Zagreb: Hrvatsko društvo prehrambenih tehnologa, biotehnologa i nutricionista, 2014. str. 17-22

Podaci o odgovornosti

Jurinjak Tušek, Ana ; Jurina, Tamara ; Čurlin, Mirjana ; Kurtanjek, Želimir

engleski

Metabolic control analysis (MCA) of the BTEX bioremediation model

Metabolic control analysis of the biological part of the Coupled Biological and Chemical (CBC) model of BTEX bioremediation was performed. Concentration control coefficients, elasticity coefficients and flux control coefficients were estimated using expression for general biochemical networks with branching (Kremling, 2014). Biochemical networks consist of number of enzyme-catalyzed reactions transforming substrates into products and quantitative understanding of these systems requires mathematical tools. Metabolic control analysis is described in literature (Hornberg et al., 2007) as a powerful theoretical and mathematical framework for understanding the relationships between the steady-state properties of biochemical networks. Metabolic control analysis quantifies the changes in metabolic variables (concentrations or fluxes) as a result of changes in system parameters (Wu et al., 2004). This methodology is used for description of relationships between network dependant properties (control coefficients) and local properties (elasticity coefficients). A control coefficients (concentration or flux) measure the relative steady-state change in system variable in response to a relative change in a parameter, while the elasticity coefficients measure the local response of the enzyme to change (substrate, product or effectors concentration). Used mathematical model of BTEX bioremediation includes 18 ordinary differential equations ; time change of each metabolite concentration is a difference between the rate of formation and consumption of individual molecules. The analysed biological part of the model describes the BTEX biodegradation by bacteria, BTEX fermentation to acetate, oxidation of acetate, methanogenesis and biomass decay. Results of the performed MCA analysis give better insight into the complex biochemical network and can be used for possible model reduction and simplification and experiment planning.

metabolic control analysis ; control coefficients ; elasticity coefficients ; BTEX

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Podaci o prilogu

17-22.

2014.

objavljeno

Podaci o matičnoj publikaciji

Proceedings of the 8th International Congress of Food Technologists, Biotechnologists and Nutritionists

Frece, Jadranka

Zagreb: Hrvatsko društvo prehrambenih tehnologa, biotehnologa i nutricionista

978-953-99725-5-5

Podaci o skupu

8th International Congress of Food Technologists, Biotechnologists and Nutritionists

poster

12.10.2014-24.10.2014

Zagreb, Hrvatska

Povezanost rada

Biotehnologija, Kemijsko inženjerstvo