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izvor podataka: crosbi

Possible target for preventing fibrotic scar formation following acute myocardial infarction (CROSBI ID 210813)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Cvjetičanin, Bruno ; Prutki, Maja ; Dumić-Čule, Ivo ; Veir, Zoran ; Grgurević, Lovorka ; Vukičević, Slobodan Possible target for preventing fibrotic scar formation following acute myocardial infarction // Medical hypotheses, 83 (2014), 6; 656-658. doi: 10.1016/j.mehy.2014.09.011

Podaci o odgovornosti

Cvjetičanin, Bruno ; Prutki, Maja ; Dumić-Čule, Ivo ; Veir, Zoran ; Grgurević, Lovorka ; Vukičević, Slobodan

engleski

Possible target for preventing fibrotic scar formation following acute myocardial infarction

Bone morphogenetic protein 1 (BMP1) was originally isolated from bone with other BMPs due to its affinity for heparin. While all other BMPs are members of the Transforming Growth Factor β (TGFβ) superfamily of growth factors, BMP1 is not an authentic member of the BMP protein family. Together with mammalian Tolloid Like protein 1 (mTLL-1) and mTLL-2, BMP1 comprise a small group of zinc- and calcium-dependent proteinases. Acute myocardial infarction (AMI) is the leading cause of death in developed countries which accounts for 13% of deaths worldwide. It was recently shown that inhibition of BMP1-3 reduces progression of fibrosis in chronic kidney disease and suggested that BMP1-3 is an important molecule for fibrogenesis. We hypothesize that inhibition of BMP1-3 represents future of therapeutic interventions in the heart tissue fibrosis following AMI. This novel approach aims to acquire the first candidate specific treatment for recuperating the heart function in patients with AMI.

acute myocardial infarction; BMP1 isoforms

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Podaci o izdanju

83 (6)

2014.

656-658

objavljeno

0306-9877

10.1016/j.mehy.2014.09.011

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Poveznice
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