engleski

Efficiency of new adamantyl tenocyclidines in organophosphate and carbamate intoxication

The tenocyclidine (TCP) and its newly synthesised adamantyl derivatives with piperidine (TAPIP), pyrolidine (TAPIR) and morpholine (TAMORF) were tested on mice poisoned with organophosphorus (OPs) and carbamates compounds. All tested compounds were applied intraperitoneally at dose 2.5 mg/kg b. w. together with atropine (10 mg/kg b.w.) or/and 1/4 LD50 of HI-6. Each tested compound applied together with atropine had good therapeutic effect in intoxication with carbamates (propoxur, aldicarb, RO2-0683) and OPs (soman and dichlorvos). The same compounds were not so effective in tabun poisoning. The best therapeutic effects with tested compounds was obtained when they were used combined with HI-6 in soman poisoned mice. Tested compounds combined with HI-6 applied together 1 min. after soman poisoning ensured survival of all animals treated with 4 up to 6.4 LD50 of soman. These results suggest that these compounds in combination with atropine or in combination with HI-6 prevent and antagonise the acute toxicity of OPs and carbamates poisoning. These results are especially interesting in carbamates poisoning because actually the drug of choice is atropine only.

organophosphorous compounds; carbamates; adamantyl tenocyclidines; intoxication; mice

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