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Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial) (CROSBI ID 210886)

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Isenberg, D ; Gordon, C ; Licu, D ; Copt, S ; Rossi, CP ; Wofsy, D ; Martinović Kaliterna, Dušanka ; Morović-Vergles, Jadranka Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial) // Annals of rheumatic diseases, 74 (2015), 11; 2006-2015

Podaci o odgovornosti

Isenberg, D ; Gordon, C ; Licu, D ; Copt, S ; Rossi, CP ; Wofsy, D ; Martinović Kaliterna, Dušanka ; Morović-Vergles, Jadranka

engleski

Efficacy and safety of atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial)

Objectives: Despite advances in systemic lupus erythematosus (SLE) treatment, many patients suffer from the disease and side effects. Atacicept is a fusion protein that blocks B-lymphocyte stimulator and a proliferation-inducing ligand, which are increased in patients with SLE. Methods: In this double-blind, placebo-controlled study, patients with moderate-to-severe SLE were randomised to atacicept 75 mg or atacicept 150 mg administered subcutaneously, or placebo twice-weekly for 4 weeks, then weekly for 48 weeks. Primary and secondary efficacy measures were the proportion of patients experiencing at least one flare of British Isles Lupus Assessment Group A or B, and time to first flare, respectively.

Autoantibodies ; Autoimmunity ; B cells ; Infections ; Systemic Lupus Erythematosus

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Podaci o izdanju

74 (11)

2015.

2006-2015

objavljeno

0003-4967

1468-2060

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost