engleski

Chronic cytoprotection: pentadecapeptide BPC 157, ranitidine and propanolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats

Unlike sever gastric damage acutely induced by ethanol administration in rat, the ulcerogenic effect of chronic alcohol administration given in drinking water, producing liver lesions and portal hypertension, far less investigated. Therefore, focus eas on the antiulcer effect of gastric pentadekapeptid BPC 157, GEPPPGKPADDAGLV, M.W. 1419, known to have a benificial effect in variety of gastrointestinal lesions models (10&mgr ; g or 10 ng/kg b.w. i.g.) ranitidine (10 mg/kg b.w. i.g.) and prpopranolol (10 mg/kg b.w. i.g.) or saline (5 ml/kg b.w. i.g. ; control)They were given once daily(1) throughout 10 days preceding alcohol consuption, (2)since beginning of alcohol drinking till the end of the study, (3)throughout the last month of alcohol consuption, 2 months after alcohol drinking had been initiated. Gastric lesions were assessed, at the end of 3 months drinking {; ; (1), (2)}; ; or with respect to therapeutic effect of medication before medication or at the end of therapy. Pentadecapeptide BPC 157, ranitidine and propranolol may prevent gastric lesion development if given prophylactically, before alcohol drinking. Likewise, they attenuate the lesion appearance given once daily throughout the drinking period. Importantly, when given therapeutically, they may antagonize otherwise pertinent lesion presence in stomach mucosa of the drinking rats. Thus, these results demonstrate thet pentadecapeptide BPC 157, ranitidine and propranolol may prevent, attenuate or reverse the gastric lesions appearance in chronically alchol drinking rats, and may be used for further therapy, while the other studies showed that their effect ( except to ranitidine) is parallel with their benificial effect on liver lesion and portal hypertension.

chronic cytoprotection; pentadekapeptid BPC 157; ranitidin; propranolol; gastric lesions; portal hypertension; rats

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