engleski

Polymorphism of Apoprotein E (APOE), Methylentetrahidrofolate Reductase (MTHFR) and Paraoxonase (PON1) Genes in Patients with Cerebrovascular Disease

Although controversial, data on the genetic polymorphism of APOE, MTHFR and PON1 genes implicate their role in the development of cerebrovascular disease. The aim of this study was to assess the association of polymorphism of APOE, MTHFR and PON1 genes in 56 stroke and 36 carotid stenosis patients, and in 124 control subjects by PCR-RFLP analysis. Considering the stroke group, a significantly different MTHFR genotype distribution (p=0.004, odds ratio for T/T of 17.571) but no significant difference in APOE and PON1 allele and genotype distribution compared to the control was found. The carotid stenosis group exhibited a significantly different APOE allele and genotype distribution (p=0.023, odds ratio APOEe3e4 of 4.24), but no significant difference in the MTHFR and PON1 allele and genotype distribution from the control group. The preliminary results obtained in this study revealed an association of the MTHFR and APOE gene polymorphism with cerebrovascular disease, suggesting a significant risk for stroke in subjects having homozygous T allele and for carotid stenosis in subjects having APOEe3e4 genotype. Additional studies in greater patient groups are needed to confirm these observations.

APOE; MTHFR; PON1; PCR-RFLP; Stroke; Carotid stenosis

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