engleski

Comparison of metabolic and endocrine parameters in patients with moderate and severe obstructive sleep apnea

The pathophysiology of obstructive sleep apnea syndrome (OSAS) has been associated with dysregulation of the hypothalamic pituitary adrenal axis and has been linked to abnormal glucose metabolism and increased diabetes risk. The aim of the current study was to compare parameters of glucose metabolism and hormonal status between moderate OSA (apnea-hypopnea index (AHI):15–30) and severe OSA (AHI > 30) patients.A total of 56 OSA patients(24 moderate and 32 severe) underwent a full-night polysomnography, oral glucose tolerance test(OGTT) and blood sampling for various metabolic and endocrine parameters. Insulin resistance was assessed by the homeostatic model assessment index of insulin resistance(HOMA-IR index).Fasting plasma glucose level(5.05±
0.
54 vs.5.41±0.67 mmol/L ; P = 0.037), HbA1c (5.4
±0.2 vs.5.7±
0.3% ; P = 0.001) and HOMA-IR index (2.68
±2.08 vs. 4.61±
3.71 ; P = 0.026) were significantly lower in moderate OSA patients in comparison with severe OSA patients. There were no statistically significant difference in insulin and postprandial glucose levels between groups. Levels of morning plasma cortisol were statistically higher in moderate OSA group(424±
145 nmol/L) comparing to severe OSA patients (303
±93 nmol/L ; P < 0.001).In conclusion we can state that the glucose metabolism was altered in both groups, but more pronou
nced in severe OSA patients while cortisol levels were higher in moderate OSA patients.

Obstructive sleep apnea ; HPAC axis

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