engleski

Gastropathy and diarrhea in diabetic patients : The presence of helicobacteriposis nad PAS-positive vascular deposits in gastric and duodenal mucosa

46 poorly controlled diabetic patients with digestive symptoms, aged 23 to 63 years (32 type I patients on insulin therapy with a mean diabetes duration of 14.2+/-3.1 years and 13 type II patients with a mean diabetes duration of 7.2+/-2.3 years were included. Of these, 17 had mainly gastropathic symptoms while 13 had diarrhea and the remaining 16 patients had non specific simptoms. Forty control individuals of sinilar age and gender were included. Biopsy specimens were taken from areas of grossly normal gastric and duodenal mucosa. Gastric mucosa samples were pathological in 38 of 46 diabetic patients (18 cases of chronic active H. pylori antral gastritis, 13 cases of chronic active H. pylori pangastritis and 7 cases of nonspecific chronic gastritis).Duodenal mucosa samples were pathological in 32/46 diabetic patients. In the control group, 21 of 40 gastric samples (5 cases of chronic active HP antral gastritis, 3 cases of chronic active HP pangastritis and 13 cases of HP-negative chronic gastritis) and 12/40 duodenal samples were pathological. Both helicobacteriosis and gastric and duodenal mucosa pathologies were significantly (p<0.01) more common in diabetic patients than in controls. PAS-positive materijal in the vascular wall of gastric (16/46 vs. 2/40 in controls) and duodenal mucosa specimens (25/46 vs. 5/40 in controls) was significantly more common among diabetics (p=0.001 for gastric and p<0.001 for duodenal mucosa). Endoscopic specimens from the gastroduodenum of diabetic patients revealed a large quantity of PAS positive vascular deposits, probably reflecting the condition of the mucosal vessels in our patients.

diabetes mellitus; gastric mucosa; duodenal mucosa; PAS reaction

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