engleski

P300 in patients with epilepsy-difference between the target and non-target answers : pilot study

The P300 is the method of choice for evaluation of cognitive processing. Determined by the latency and amplitude of evoked responses N1, N2 and P3. Epilepsy and antiepileptic drug use reduces cognitive function. Therefore, the object of our interest is the impact of disease and drugs on P300, latency and amplitude of evoked responses. The study includes 20 subjects of both sexes, who are being treated for epilepsy, grand mal type. Everyone we have done recording auditory cognitive evoked potential, audio-P300. The measurement was done on the machine Medelec Synergy – Oxford Instruments apparatus. All subjects were determined target and not target-evoked response. All subjects were recorded auditory cognitive evoked potentials, with clear auditory stimuli regular and irregular click stimuli to which they should pay attention. The study includes 20 patients, six women and 14 men. The mean age of examinees was 56 € 3.4 years. Median duration of disease was 14 € 3.6 years. Latency of nontarget evoked response was 323.6 € 3.1 ms, a target response 295.35 € 2.7 ms. Discussion: The research revealed that the latency of nontarget auditory stimuli of cognitive, audio-P300, is longer than the target audio-P300 evoked responses in patients with epilepsy. From these results we conclude that patients with epilepsy direct their attention have appropriate cognitive response. However, if they do not direct attention their cognitive response was significantly worse than expected. Epilepsy and long-term use of antiepileptic drugs affect the characteristics of audio-P300 nontarget responses, and significantly prolonged latency of cognitive evoked response.

P300, epilepsy, evoked potentials, target and non target answers, antiepileptic drugs , cognitive evoked response

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