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izvor podataka: crosbi

Expression of nestin in superior cervical ganglia of rats is influenced by gender and gonadectomy (CROSBI ID 212647)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Filipović, Natalija ; Mašek, Tomislav ; Grković, Ivica Expression of nestin in superior cervical ganglia of rats is influenced by gender and gonadectomy // Journal of chemical neuroanatomy, 63 (2015), 6-12. doi: 10.1016/j.jchemneu.2014.11.003

Podaci o odgovornosti

Filipović, Natalija ; Mašek, Tomislav ; Grković, Ivica

engleski

Expression of nestin in superior cervical ganglia of rats is influenced by gender and gonadectomy

Neurons and glia arise from neural progenitor cells that express nestin. Although substantial changes in neuronal development were observed during the postnatal period, data concerning dynamics of nestin expression in the superior cervical ganglia (SCG) of rat during that period are lacking. It is known that gonadectomy and steroid hormones influence the development of neurons in the SCG during the postnatal period, but there are no data on how they influence the persistence of nestin expression in the SCG cells. The dynamics of nestin expression in the SCG, as well as the influence of gender and gonadectomy, was investigated in rats of three age groups. Three goups of male rats were sacrificed at 2, 3 and 6 months of age. Additional goups of male and female Sprague-Dawley rats were gonadectomized at the age of two months. After 30 days, they were sacrificed and SCGs were harvested and processed immunohistochemically. Immunoreactivity for nestin in the SCG was observed in satellite glia, based on their expression of s100. The proportion of neurons that were encircled with nestin-immunoreactive satellite cells (nestin encircled neurons, NEN) decreased between 2nd and 3rd month of age (p<0.05). The proportion of NEN was greater in the NPY+ than in the NPY- subpopulation. The proportion of NEN in the SCG of female rats was significantly higher (p<0.05) than that of both, the male rats and ovariectomised groups. The percentage of these neurons was significantly higher (p<0.05) in orchidectomised, in comparison to male rats. Results show the existence of nestin- immunoreactive satellite cells in the SCG of adult rats. A substantial decrease of nestin expression in SCG cells of rats, after the onset of sexual maturation, was observed. This decrease showed significant sex-dependence and was dramatically influenced by gonadal activity.

superior cervical ganglion; nestin; satellite cells; age; gender; gonadectomy

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Podaci o izdanju

63

2015.

6-12

objavljeno

0891-0618

10.1016/j.jchemneu.2014.11.003

Povezanost rada

Temeljne medicinske znanosti, Veterinarska medicina

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